We have synthesized five new 2-acetyl-6-methoxypyridine thiosemicarbazone (AMOPY-TCS’s) compounds, and characterized them by proton NMR spectroscopy. These new compounds have been used as ligands in reactions with Cu(II) to form new metal complexes. These copper complexes have the overall formula [Cu(AMOPY-TCS)Cl] and we have shown them to have high antiproliferative activity against microbes, especially gram positive bacteria. We believe these copper complexes have inhibitory activity against certain enzymes that are necessary for replication. The minimum inhibitory concentrations of each compound was determined with four bacteria (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa), two yeast (Candida albicans and Saccharomyces cerevisiae), and a mold (Aspergillus niger).

Comparison of a series of 2-acetyl-6-methoxypyridine (AMOPY) thiosemicarbazone ligands and their Cu(II) complexes

251st National Meeting (2016)

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