The desire to find a suitable replacement for palladium in cross-coupling reactions has resulted in a large body of work involving metals such as iron and cobalt. These two metals are desirable as they are less expensive and more benign than palladium. cobalt-catalyzed Kumada couplings have been reported but typically require higher catalyst loading (5 mol%) than palladium-based systems. With an understanding of how the Schlenk equilibrium impacts the cobalt-catalyzed Kumada couplings we have been able to develop conditions that work at lower catalyst loadings. The benefits and limitations of these conditions will be discussed.

Studies aimed at lowering the catalyst loading in cobalt-catalyzed Kumada coupling reactions

251st National Meeting (2016)

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