The success of a targeted radiotherapy system depends on its ability to carry and deliver its radioactive payload to a specific site. In this work, the stability of gold-coated lanthanide phosphate (LuGdPO4@Au) nanoparticles loaded with 177Lu is presented, as an analog for a system using the α-emitter 225Ac. Also presented is the system’s biodistribution in mice as well as the ability to alter that biodistribution by conjugating different sized PEG-linkers to the gold-surface. The nanoparticles are synthesized by the co-crystallization of orthophosphate and lanthanide metal ions and gold-coated by reduction of NaAuCl4 with sodium citrate. The nanoparticles retain &gt;95% of the 177Lu after two weeks in milli-Q water, PBS, and FBS. The tunability of the biodistribution has been demonstrated by altering the PEG length from 800Da to 3400Da. Future experiments will target nanoparticles specifically to cancer cells using antibodies.

177Lu-doped lanthanide phosphate nanoparticles (177LuGdPO4@Au) for targeted radiotherapy

251st National Meeting (2016)

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