Oleanolic acid is a naturally acquired triterpenoid compound that has been known to show biological activities such as anti-cancer, anti-viral and hair restoring effect etc. Enzymatic activity of 5-α-reductase has been recognized as an important factor in aggravating alopecia. Oleanolic acid has been reported to inhibit the enzymatic activity of 5-α-reductase. We prepared oleanolic acid analogs and investigated their biological activity in various in vitro settings. We identified potant oleanolic acid analogs that are effective in inducing hair restoration.

Synthesis of oleanolic acid derivatives for inducing hair restoration

251st National Meeting (2016)

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