Vibrational spectroscopy has been a powerful tool for quantitative analysis of molecules in gas phase or solutions and has been deployed for label-free analysis of excised biological tissues. Yet, applying vibrational spectroscopy to non-invasive in vivo imaging, from single live cells to the human body, is still difficult. I will present our persistent efforts in developing in vivo spectroscopic imaging platforms that have been enabling groundbreaking biological discoveries and paradigm-shifting diagnosis strategies. Specifically, I will present coherent Raman scattering microscopy for real-time spectroscopic imaging of living cells, vibration-based photoacoustic endoscopy/tomography for bond-selective imaging of deep tissues, and transient absorption imaging of nanomaterials.

In vivo vibrational spectroscopic imaging: Emerging platform for biology and medicine

251st National Meeting (2016)

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