Due to their high integrity, facile surface chemistry, excellent stability, and combined properties from the core and shell, magnetic-plasmonic core-shell nanoparticles are promising for applications in many areas including catalysis, energy conversion, biological separation, medical imaging, cancer detection and treatment. Here we report a facile method to prepare magnetic-plasmonic iron oxide-gold core-shell nanostructures in different sizes and shapes including sphere, popcorn and star. The nanostars exhibit greatest optical tunability and strength, followed by popcorns and spheres. Using spiked cancer cells in human whole blood, we demonstrate that the anisotropic iron oxide-gold hybrid nanoparticles allow on-line magnetic separation and surface enhanced Raman scattering detection of circulating tumor cells, with the detection sensitivity down to 1-2 cells per milliliter of blood. We further demonstrate the capability of the hybrid nanoparticles for multiplexed multicolor detection of surface protein markers on cancer cells at the single cell level using the highly sensitive and specific surface enhanced Raman scattering technology

Magnetic-plasmonic core-shell nanoparticles: Shape-controlled synthesis, properties and applications in cancer detection

251st National Meeting (2016)

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