Decarboxylative coupling represents a powerful method for the construction of C–C bonds, and has gained special appreciation in non-fluorous chemistry. This strategy exhibits several appealing features, including: 1) the use of inexpensive and readily accessible starting materials; 2) the ability to selectively generate and couple reactive species under mild reaction conditions; 3) the release of CO<sub>2</sub> as a benign and easily removed by-product. Using both Pd- and Cu-based catalysts, we present new decarboxylative reactions for accessing trifluoromethanes and fluoroalkyl ketones.

Metal-catalyzed strategies for decarboxylative fluoralkylation

251st National Meeting (2016)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.