The interaction of amino acids with phospholipid interfaces is inevitable in many biological systems. Both free amino acids and amino acids incorporated into proteins interact with biological membranes. These interactions are important for understanding proper protein function, as well as deleterious assemblies associated with a variety of disease states such as Phenylketonuria or Alzheimer’s.<br/><br/>This presentation describes interface sensitive experiments examining the role of amino acids, specifically aromatic amino acids such as phenylalanine, in altering interfacial properties and function. Models for membranes used include dipalmitoylphosphatidylcholine (DPPC) monolayers at the surface of water as well as vesicles with bilayered DPPC membranes. Interfacial partitioning, organization, aggregation and permeability are all considered in light of biological functions and diseases.

Interactions of aromatic amino acids with phospholipid monolayers and bilayers

251st National Meeting (2016)

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