Samples of microcrystalline cellulose, MCC, combined with 5% or 10% ethyl cellulose and 10% naproxen were granulated, extruded, and spheronized into wet sustained release beads. These wet beads were then exposed to convection oven drying and stored in a freezer. The rate of naproxen release from the MCC/EC bead systems was measured by dissolution methods using a buffer series with pH ranges of 2.0 to 8.0 as the solvent system. The control for this experiment was the convection oven dried MCC beads. The results observed, based on these dissolution studies, suggest that the rate of naproxen release from each MCC/EC dried bead system either increases, decreases, or follows the same release rate as the control sample. This further suggests that the rate of release of naproxen from each MCC/EC sample depends upon the pH conditions to which the dry bead systems were exposed.

Investigation of the effect pH has on the release mechanism of naproxen from ethyl cellulose/microcrystalline cellulose beads

251st National Meeting (2016)

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