School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457 The development of nanostructured probes with unique optical, electronic, and magnetic properties has opened up new possibilities for molecular imaging and spectroscopic detection of specific targets in biomedical and environmental applications. Surface enhanced Raman scattering (SERS) that allows for detecting fingerprint vibrational spectra of single molecules has emerged as a powerful technique for ultrasensitive detection. Plasmonic metal nanostructures with confined electromagnetic field arising from localized surface plasmon resonance (LSPR) are compelling SERS substrates under intense research. This talk summarizes our recent work in developing a new class of core-shell metal nanoparticles with an interior, Raman tag-encoded nanogap. Our strategies take advantage of nanoparticle-templated self-assembly of amphiphilic block copolymers and redox-active polymer coating for tailored nanogap engineering for greatly improved SERS activity.1-3 1. Song, J. B.; Duan, B.; Wang, C. X.; Zhou, J. J.; Pu, L.; Fang, Z.; Wang, P.; Lim, T. T.; Duan, H. W. SERS-Encoded Nanogapped Plasmonic Nanoparticles: Growth of Metallic Nanoshell by Templating Redox-Active Polymer Brushes. J. Am. Chem. Soc. 2014, 136, 6838-6841. 2. Song, J. B.; Pu, L.; Zhou, J, J.; Duan, B.; Duan, H. W. Biodegradable Theranostic Plasmonic Vesicles of Amphiphilic Gold Nanorods. ACS Nano 2013, 7, 9947-9960. 3. Song, J. B.; Zhou, J. J ; Duan, H. W. Self-Assembled Plasmonic Vesicles of SERS-Encoded Amphiphilic Gold Nanoparticles for Cancer Cell Targeting and Traceable Intracellular Drug Delivery J. Am. Chem. Soc. 2012, 134, 13458-13469.

Nanogapped plasmonic nanoparticles: Towards tailored nanogap engineering

251st National Meeting (2016)

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