Living organisms carry out the <i>de novo</i> synthesis and subsequent remodeling of phospholipid membranes. The development of comparatively dynamic artificial lipid membranes will require simple methods to mimic how native phospholipid membranes are synthesized and remodeled. We have developed several strategies to generate lipid membranes from reactive precursors using chemoselective coupling reactions. Using reversible coupling reactions, we have also been able to sequentially form and remodel artificial lipid membranes. Interestingly, <i>in situ</i> remodeling of phospholipids is capable of controlling micrometer scale changes in vesicle spatial organization, composition and morphology.

De novo lipid membrane synthesis using chemoselective reactions

251st National Meeting (2016)

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