Laser-induced retinal damage causes death and/or injury of photoreceptor and retinal pigment epithelium (RPE) cells.  This damage releases proteins into systemic circulation, which permits the identification of candidate biomarkers through Matrix-Assisted Laser Desorption/Ionization Time-of-Flight (MALDI-TOF).  This project identified candidate biomarkers for laser-induced retinal damage using Mass Spectrometric Imaging.  Protein and lipid profiles in healthy and damaged ocular tissue were characterized for the identification of potential biomarkers.  The specific identification of panel biomarkers for laser-induced retinal damage can provide basis for development of a minimally invasive diagnostic test to detect acute retinal damage in affected humans.

Investigation of biomarkers indicative of laser-induced retinal damage by using mass spectrometric imaging

251st National Meeting (2016)

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