Natural products continue to serve as important sources of bioactive molecules and pharmaceuticals.  Recent genome sequencing efforts and the vast genome resources revealed both fungal and bacterial species encode signficantly more natural product biosynthetic pathways than the number of natural products that have been isolated.  This indicates under typical fermentation conditions, a large proportion of these pathways are silent, hence preventing the biosynthesis of the corresponding metabolites.  We have used different strategies to activate these pathways at the transcription level, including heterologous biosynthesis, epigenetic activation, pathway-specific transcription factor overexpression, etc.  Some recent progress in mining fungal natural products will be discussed in this talk.

Strategies toward discovering new natural products from fungal species

251st National Meeting (2016)

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