Two topics will be presented regarding two different types of inorganic nanomaterials for biomedical applications. In the first part, the magnetically induced internal heating of mesoporous silica nanoparticles is quantified by an optical ratiometric method based on lanthanide doped upconversion nanocrystals. Upon placing in an oscillating magnetic field, the Fe3O4 nanocrystals introduce temperature change, which is measured by the temperature-dependent luminescence emissions of NaYF4:Yb3+,Er3+ nanocrystals. A stepwise phase transfer method is developed to incorporate both of the nanocrystals. The magnetic heating performance is examined under different experimental conditions, including the magnetic field induction power, the exposure time to the magnetic field, and the magnetic nanocrystal size. The interior temperature of silica nanoparticles is monitored continuously during the exposure to magnetic field, and is found to be higher than that of the macroscopic solution. The gradient quickly disappears after the magnetic field is turned off. This continuous absolute temperature detection method offers quantitative insight into the nano environment around magnetic materials and opens a path for optimizing local temperature controls for physical and biomedical applications. In the second part, a multiplexed molecular detection platform based on the fluorescent emissions of single wall carbon nanotubes will be presented. The carbon nanotubes are non-covalently modified with chelating group nitrilotriacetic acid and Cu2+ ions. By conjugating a recognition moiety with the Cu2+ ion, the carbon nanotubes are capable of specifically recognize the target analyte transduced by their changed fluorescence emission properties. Moreover, we have developed a miniature microarray system to integrate multiple recognition sites onto a small area of glass slide. Using only a few microliter of the sample, we are able to quickly detect multiple analytes using our nanosensor platform. The label-free detection system will be of great potential for product quality control and clinical diagnosing applications in the future.

Taking the temperature of the interiors of magnetically heated nanoparticles and multiplexed biomolecular sensing using single wall carbon nanotubes

252nd National Meeting (2016)

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