The emergence of resistant bacterial strains is a real problem to human health. A problematic bacterial strain is MRSA (methicillin resistant staphylococcus aureus), a type of infection resistant to many current antibiotics.<br/>The identification of new drugs that can prevent and inhibit MRSA growth is key to solve this health challenge. The endophenazines are heterocyclic antibiotics of natural origin that have shown promising results against various bacteria including MRSA.<br/>This poster presents the design and a concise synthesis of the endophenazine natural products. In order to develop structure-activity relationships, we prepared a series of structural analogues. The biological evaluation and the physical properties of the synthesized compounds are presented. Some of the endophenazines present MIC in the low micromolar range and limited toxicity against mammalian cells. The obtained data indicates the potential of the endophenazines as potential new drugs against MRSA.

Synthesis and development of the endophenazines as new antibacterial drugs

252nd National Meeting (2016)

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