Rice bran is a functional food that includes both nutritional and medicinal benefits across the lifespan, and has shown protection against major chronic diseases (e.g. obesity, diabetes, cardiovascular disease and cancer) in animal and human studies.  Identification of the phytochemical diversity of rice bran associated with medicinal properties is possible through global metabolome investigations and will aid this global dietary solution to be further tested for disease control and prevention. This study was performed to establish the medicinal roles for rice bran compounds across diverse metabolic pathways using metabolomics.<br/>The aim of this study was to perform a non-targeted global metabolite profile of rice bran from three US rice varieties and compare then to a global-grown set of 16 varieties from 7 different geographical locations using Ultra-performance liquid chromatography mass-spectrometry (UPLC-MS).  The evaluated rice bran metabolome contained ~446 phytochemicals, of which 217 phytochemicals were associated with the following metabolic subclasses: Amino acids, Cofactors & Vitamins and Xenobiotics. This analysis revealed 76 rice bran metabolites that merit consideration for pharmacological and medicinal properties. Some of the medicinal compounds with varying relative abundance in rice bran included gamma-aminobutyric acid (GABA), 5-oxoproline, rhapontigenin, trans-urocanate, N-acetylleucine, gentisate, N-acetylserotonin, N-acetyl histidine, 2-piperidinone, stigmastanol and luteolin. These molecules have established health benefits such as anti-convulsive, improving blood circulation, anti-hyperlipidemic, UV protectant, vertigo treatment, antirheumatic, anti- insomnia, anti-cataract formation, anti-hypertensive and cancer chemopreventive, respectively. Human clinical trials that evaluate the medicinal potential and bioavailability of these rice bran compounds are thus warranted.<br/>Global rice varietal differences may contribute to inconsistent results on the biochemical numbers and structures of rice bran with medicinal actions, and reported results will further incorporate genetic and environmental variability into the presentation.

Heat-stabilized rice bran metabolome reveals biochemical contents and metabolic pathways with medicinal properties

252nd National Meeting (2016)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.