Hollow mesoporous silica nanoparticles (HMSNs), as one of the most promising drug carriers, have attracted much attention due to their uniform mesopores, large surface area, excellent biocompatibility, improved loading capacity and easy modification, etc. HMSNs can act as carriers for drug delivery and vaccine adjuvants, markedly improving the antiumor immunity.<br/>We will introduce a facile yet effective method to generate monodisperse HMSNs and load multiple peptides, including hydrophobic and hydrophilic peptides. To improve the biocompability of the HMSNs, the peptides loaded HMSNs were coated with lipid bilayers (HMLBs) containing monophosphoryl lipid A adjuvant. Through this experimental design, the resulting HMSNs displayed improved cellular uptake ability and enhanved activation of both tumor specific CD8+ and CD4+ T lymphocytes. In addition, the formed HMLBs greatly inhibited tumor growth and lung metastasis in murine melanoma models. Thus, HMLBs provides a promising platform for co-delivery of multiple peptides, adjuvant and enhancement of anti-tumor efficacy of conventional vaccinations.

Synthesis of hollow mesoporous silica nanoparticles and their application for delivery of multiple peptides for melanoma immunotherapy

252nd National Meeting (2016)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.