A novel method for the stereoselective synthesis of decarboxylative trifluoromethylation of various arylpropiolic acids by using a stable and efficient Togni’s reagent/DMF reaction system was developed. The reaction shows high E/Z selectivity and wide substrate tolerance.

Iron-catalyzed decarboxylative trifluoromethylation for the synthesis of C<sub>vinyl</sub>–CF<sub>3</sub> compounds with togni (II) /DMF system

252nd National Meeting (2016)

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Iron-catalyzed decarboxylative trifluoromethylation for the synthesis of Cvinyl–CF3 compounds with togni (II) /DMF system

Iron-catalyzed decarboxylative trifluoromethylation for the synthesis of C_vinyl–CF₃ compounds with togni (II) /DMF system