The Synthetic Chemistry Core Facility at Albert Einstein College of Medicine provides synthesis capabilities to the scientific community at Einstein and for our external collaborators. This poster will highlight several of our recently completed projects in drug discovery and chemical biology.<br/>We have recently synthesized a library of chloroquine (CQ) analogs for use as autophagy inhibitors. Inhibition of autophagy has emerged as a viable strategy in cancer treatment. CQ has been used in multiple clinical trials, but suffers from low potency. Our lead compound is 8 times more potent than CQ against lung- and pancreatic-cancer cell lines. An azide-alkyne cyclization was just for late stage derivatization with a library of azides. Ongoing studies focus on optimization of the alkyne coupling partner as well as pharmacokinetic studies.<br/>Our contributions to chemical biology include ligands for CuAAC click reactions, and synthesis of several azide and alkyne containing unnatural monosaccharides for studies of various glycans.

Synthetic chemistry core at Albert Einstein College of Medicine. Recent contributions to chemical biology and drug discovery

252nd National Meeting (2016)

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