Antimicrobial films have been used for wound healing, medical devices and food industry. Here, we report a simple and eco-friendly strategy for generating protein film by nanoimprint lithography (NIL), serving as a scaffold for chlorination or a reservoir for drug loading. Protein-based films are inherently biocompatible and biodegradable. After NIL process, protein films were stable in aqueous solution, and resisted to bacteria adhesion. The diversity of amino acids on protein building blocks enables the post-functionalization and the control of payload release. After chlorinating by sodium dichloroisocyanurate or loading with antibiotics, the protein films showed antimicrobial activity, inhibiting bacterial growth via the slow release of biocides. This strategy uses natural abundant biomaterials as precursors, requires no synthetic expertise, works under aqueous conditions, and is eligible for roll-to-roll processing, which is promising for large-scale antimicrobial coating fabrication.

Antimicrobial coating fabricated by protein films

252nd National Meeting (2016)

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