Regioselective functionalization of carbon-carbon multiple bonds are of prime importance for the synthesis of variety of organic compounds including bio-active molecules. The first row nontoxic and inexpensive transition metal Iron (III) was used to catalyze the formation of a,a-dihalodimethyl ketals and alpha,alpha-dihaloketones from alkynes in excellent yield and regioselectivity. It was discovered that alkynes also can be selectively functionalized to alpha-haloketones by employing Au (III) catalyst. The power of the diverse functionalization of alkynes is that it opens a door between alkyne chemistry and carbonyl chemistry, and these multicomponent, tandem approaches allow the efficient access to structurally interesting and bioactive agents.<br/>

Transition metal catalyzed halo-functionalization of alkynes

252nd National Meeting (2016)

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