After PhD work in organic chemistry with Prof. Murray Goodman at University of California at San Diego, I did post-doctoral research at Stanford University under the supervision of Prof. Xiaoyuan (Shawn) Chen. In 2008, I launched my independent career at the University of Wisconsin - Madison and The Molecular Imaging and Nanotechnology Laboratory (http://mi.wisc.edu/) is mainly focused on three areas: 1) development of multimodality molecular imaging agents; 2) nanotechnology and its biomedical applications; and 3) molecular therapy of cancer. In the Bioconjugate Chemistry Lecture Symposium at the 2016 Fall ACS Meeting which recognizes the exceptional achievement of Xiaoyuan (Shawn) Chen, my mentor, friend, and role model for the last 12 years and many more decades to come, I will present our recent work on molecular imaging and image-guided drug delivery in cancer and various cardiovascular diseases with peptides, proteins, and nanomaterials. The primary imaging techniques used in these studies are positron emission tomography (PET), photoacoustic tomography (PAT), optical imaging, and magnetic resonance imaging (MRI). Some of the major molecular targets that we focus on are CD105 (i.e. endoglin), VEGFR, CD146, c-Met, integrin αvβ3, among others. The nanomaterials that will be discussed in this presentation may include silica-based nanoparticles, nano-graphene oxide, micelles, iron oxide nanoparticles, 2-D nanomaterials, hybrid nanomaterials, among many others. Lastly, the emerging paradigm of intrinsically radiolabeled nanomaterials will be discussed as multi-modal PET/MRI, PET/PAT imaging agents, as well as for theranostic applications.

Molecular imaging, image-guided drug delivery, and theranostics

252nd National Meeting (2016)

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