LNA (locked nucleic acid) and the corresponding 2’-amino-LNA both mediate strong nucleic acid hybridization capabilities and the latter furthermore the opportunity of attachment of a variety of functional groups along nucleic acids. It will be presented how these key features can be used to engineer specific properties into therapeutic oligonucleotide drug candidates and nucleic acid building blocks, exemplified by novel lipophilic 2’-amino-LNA-based antisense compounds and exploratory protein mimics, respectively. For a review on LNA see M. A. Campbell and J. Wengel, Chem. Soc. Rev. 2011, 40, 5680, and for a review on 2’-amino-LNA see I. K. Astakhova and J. Wengel, Acc. Chem. Res. 2014, 47, 1768.

Locked nucleic acid (LNA) in drug discovery and nanotechnology

252nd National Meeting (2016)

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