Benzo[b]thiophenes are the starting compounds for a variety of biologically active molecules. Some of its properties include antitumor, antifungal, and antithrombotic. An environmentally benign reaction of copper(II)sulfate pentahydrate and sodium halide in ethanol was used to produce a diverse library of dihalo-substituted benzo[b]thiophene derivatives. Dihalo-substituted benzo[b]thiophenes can potentially be derivatized using various metal-mediated cross coupling reactions to generate a diverse library of biologically and materially useful molecules.

Convenient synthesis of dihalo-substituted benzo[b]thiophenes via electrophilic cyclization

253rd National Meeting (2017)

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