<i>Eugenia jambolana</i> L. (Jamun) is an important summer fruit associated with many health and medicinal benefits, including anti-diabetes, anti-cancer, and anti-heart disease. Our previous phytochemical work revealed that Jamun fruit was enriched with pentacyclic triterpenoids. The aim of the current study was to determine the anti-diabetic effects and the potential mechanisms of triterpenoid-enriched Jamun fruit extract (TJFE) by using the streptozocin (STZ)-induced diabetic mice. Compared with control group, fasting hyperglycemia, glucose tolerance, insulin release and HOMA-β index were all significantly improved in TJFE-treated group (gavage, 200 mg/kg). Quantitative real-time PCR demonstrated that the induction of gluconeogenic genes expression, including Phosphoenolpyruvate carboxykinase, Glucose 6-phosphatase, Peroxisome proliferator-activated receptor gamma coactivator 1-α, and Glucokinase were also robustly abolished in STZ-induced diabetic mice after TJFE administration. The current study suggests that the pentacyclic tritrepenoids of Jamun fruit may play an important role against the development of STZ-induced type I diabetes in mice, which may serve as a potential anti-hyperglycaemic agent in diabetes care.

Triterpenoid-enriched fruit extract of <i>Eugenia Jambolana</i> L. (Jamun) attenuates experimental type I diabetes in mice

253rd National Meeting (2017)

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Triterpenoid-enriched fruit extract of Eugenia Jambolana L. (Jamun) attenuates experimental type I diabetes in mice