Manipulation of the surface properties of biominerals is very important for their biomedical applications. However, the straightforward preparation of a multifunctional and stable coating on biominerals remains a challenge. Here, a rapid and universal method for multifunctional coatings was developed based on a salivary acquired pellicle (SAP) inspired dendrimer. The dendrimer has a highly branched structure and an external surface modified with DDDEEKC peptide sequence. It mimics the adsorption function of statherin, which is one of the main components of salivary acquired pellicle, to endow the coating with a universal capability for adhesion on biominerals. The coating can be formed by a simple dip-coating method on various biominerals within 10 min, and is stable for more than one month. It also provides a universal platform of secondary modifications for different applications.

Universal multifunctional coating of biominerals based on salivary acquired pellicle inspired dendrimer

253rd National Meeting (2017)

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