In solution, siderophores like desferrioxamine B (DFOB) are avid binders of Ti(IV), and DFOB can solubilize Ti(IV) from the surface of solid TiO2. Such dissolution could render bioactive Ti(IV) biologically available, and could interfere with Fe(III) biogeochemical cycling. Suspensions of different forms of TiO2 were exposed to DFOB, and monitored by UV/Vis spectroscopy and ICP-OES to determine the binding and kinetics of Ti-DFOB formation. Introduction of small organic acidic ligands such as oxalate, citrate, ascorbate and succinate changed the dissolution kinetics, suggesting a synergistic cooperation particularly between oxalate-DFOB dissolution. Exposure to cosmetic products that contained TiO2, such as sunscreen, was also investigated to determine biological effects of siderophore binding. Surface analysis of DFOB with TiO2 were obtained using SEM and TEM. ESI-MS confirmed Ti-DFOB in solution. Understanding these interactions is necessary to determine the effects of binding, the interaction of these complexes in aqueous environments and how they behave chemically in biological systems.

Siderophore-Promoted release of titanium(IV) from metal oxide materials

253rd National Meeting (2017)

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