Supercritical fluid extraction (SFE) is widely used as an analytical method for extracting natural products from different matrices. The main advantages of using SFE compared to traditional sample extractions such as liquid-liquid extraction, soxhlet extraction, SPE are less sample handling, sample stability, and higher efficiency.  Here we will demonstrate the application of online SFE/SFC for pharmaceutical and food samples. Coupling of SFE-SFC-MS system, solid and liquid samples were extracted by SC-CO<sub>2</sub> with the addition of co-solvent modifier and analyzed directly by SFC-MS. Different parameters were assessed: temperature of the vessel chamber, pressure of the extraction fluid, time of extraction and gradient, and co-solvent modifier concentration.<br/>

Online Supercritical Fluid Extraction/Supercritical Fluid Chromatography (SFE/SFC) for pharmaceutical and food sample analysis

253rd National Meeting (2017)

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