A simple and efficient procedure for the synthesis of biaryl seven-membered lactones under microwave-promoted is reported. The umpolung reaction was promoted by N-heterocyclic carbenes under oxygen, with anhydrous potassium carbonate as base and with 1,4,7,10,13,16-Hexanoxacyclooctadecane (18-crown-6) as a phase-transfer catalyst. The practical protocol was found to be compatible with different structurally diverse substrates. Moderate to excellent yields, operational simplicity are the main highlights.

Microwave-promoted/assisted method for rapid prepararation of biaryl seven-membered lactones

253rd National Meeting (2017)

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