The aim of this study is to exploit a Good’s buffer ionic liquid-containing system for efficient production of (R)-[3,5-bis(trifluoromethyl)phenyl] ethanol [(R)-BTPE] from 3,5-bis(trifluoromethyl) acetophenone (3,5-BTAP) catalyzed by T. asperellum ZJPH0810 cells. A new type of quaternary ammonium-based ILs (QAILs) were investigated and compared with more conventional imidazolium or pyridium-based ILs.[N1,1,1,1]+ come up as a Good’s buffer of cation to the T. asperellum ZJPH0810 cell in the bioreduction of 3,5-BTAP to (R)-BTPE. After selection and optimization, the highest concentration of substrate and product for the bioreduction observed in [N1,1,1,1][PF6]-containing system were 75 mM and 65.4 mM, which is 1.5-fold and 1.4-fold increase in contrast to that in monophasic aqueous system, respectively.[N1,1,1,1][PF6] was considered to be a Good’s buffer IL for the T. asperellum ZJPH0810-catalyzed bioreduction owing to its good biocatalytic reduction results and excellent cell biocompatibility.

Exploit ionic liquids to significantly improve asymmetric reduction of 3,5-bis(trifluoromethyl) acetophenone catalyzed by T. asperellum ZJPH0810 cells

253rd National Meeting (2017)

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