A new and versatile family of cellulosic excipients (AFFINISOL™, The Dow Chemical Company) has been designed and commercialized for delivery of pharmaceutical actives with poor water solubility. Some of these excipients are targeted for spray-dried dispersion (SDD) processing while others are targeted for hot-melt extrusion (HME) processing. The solution rheology of selected excipients is explored at spray-drying conditions to understand their performance and to accelerate selection of options (solvent, excipient, and excipient concentration) for new actives. Similarly, the rheology of selected excipients is explored at HME conditions. These HME excipients are thought to be yield-stress fluids when processed at temperatures above their glass-transition temperature <i>T</i><sub>g</sub>. These stresses are easily achieved in twin-screw extruder setups often used for hot-melt extrusion by the pharmaceutical industry.

New family of cellulosic excipients for poorly-soluble actives

253rd National Meeting (2017)

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