Todate, there is no permanent cure for cancer and billions of dollars are spent each year to treat or improve the quality of life of those afflicted. Several drugs are in clinical trials in finding effective treatments and diagnostics for early detection. Photodynamic therapy (PDT) is one of the approved cancer therapy which has the potential to selectively destroy malignant cells while sparing the normal tissues. Hyaluronic acid (HA) is a naturally occurring high molecular weight linear polysaccharide with D-glucuronic acid and N-acetyl-D-glucosamine as repeated units linked by an α-1,3-glycosidic bond and is known to direct drugs to cancers that express CD44 receptors. In our study we conjugated porphyrin to high and low molecular weight HA efficiently and studied their efficacy in both two dimensional (monolayer) and three dimensional (spheroids) cell culture.

Synthesis and two- and three-dimensional <i>in vitro</i> studies of hyaluronic acid porphyrin conjugates

253rd National Meeting (2017)

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Synthesis and two- and three-dimensional in vitro studies of hyaluronic acid porphyrin conjugates