Himeradine A was isolated from the club moss <i>Lycopodium chinense </i>by the Kobayashi group in 2003. Its skeletal framework features ten stereogenic centers, including one all-carbon quaternary stereocenter. Initial studies reported that Himeradine A exhibited moderate cytotoxicity against murine lymphoma L1210 cells (IC<sub>50</sub> = 10µg/ml), however in-depth biological screening has yet to be performed. To date, there has been one total synthesis reported by the Shair group. Herein, we disclose our highly convergent approach towards Himeradine A.

Progress towards the total synthesis of himeradine A

253rd National Meeting (2017)

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