The rhodium(III) catalyst tris(acetonitrile)pentamethylcyclopentadienylrhodium(III) hexafluoroantimonate [Cp*Rh(MeCN)3](SbF6)2, reacts with 1-(2H)-phthalazinones to promote a C-H functionalization event at C8. The preparation of a set of compounds arising from oxidative alkenylation with olefins, hydroarylation with alkynes, and iodination with N-iodosuccinimide are reported. Notably, this strategy enables rapid preparation of C8-substituted phthalazinones without requiring phthalazinone ring synthesis starting from a pre-functionalized arene.

Rhodium(III)-catalyzed C-H functionalization of 1-(2H)-phthalazinones at C8

253rd National Meeting (2017)

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