Composite nanoparticles coated with chitosan/ alginate beads were developed to target and deliver chemicals throughout the human body by modifying the particle surface with antibiotics or with nutrient supplements. Numerous reports relating bacteria in humans have increased over the last years. Bacteria resistant to antibiotics and antibacterial materials are of great interest but high level of complexity in their production. In this paper biocomposites magnetic materials was developed to achieve a surface with antibacterial properties. The synthesis of this matrix was derived with the following proportions 1.5 grams of medium molecular weight chitosan, alginate 1 gram of acid, and 1 gram of magnetite (Fe3O4) nanoparticles. This proportion was optimized and analytical techniques were used to link relate the surface with the growth rate of E. coli in the petri dish with Tryptic Soy Agar. Analytical techniques such as infrared spectroscopy, liquid chromatography hyper-performance were used to determine the efficiency of absorption of the antibiotic oxytetracycline. Antibacterial activity is related to compounds kill bacteria or that locally their growth slow down, without being in generally toxic to surrounding tissue. Preliminary results show that 78.3% of antibiotics were removed from aqueous solution with the chitosan/alginate magnetic beads. One of the first test it was observed an inhibition halo and its correlation on the growth of E. coli. Further studies are required to examine swelling of different beads as the function of inhibition ring and growth rates of E. coli.

Effect of magnetite chitosan/alginate beads infused with the antibiotic oxytetracycline hydrochloride on E. coli growth rates

253rd National Meeting (2017)

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