We report on the design of bioactive glycosylated gold nanoparticles via a combination of RAFT polymerization, carbohydrate ligation through reductive amination and thiol-gold self-assembly. This approach is used for the design of gold nanoparticles decorated with the complex sialylated glycan Neu5Ac-α-2-6-Gal, and we demonstrate multivalent and specific recognition between the nanoparticles, lectins and hemagglutinin on the surface of the influenza virus. These nanoparticles could be used to further extends the ‘glyco’-armory for the development of therapeutic or diagnostic applications or for fundamental studies looking at carbohydrates interactions.<br/><br/>

Influenza-binding sialylated nanoparticles by combination of RAFT polymerization, reductive amination and gold-thiol self-assembly

253rd National Meeting (2017)

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