In the past, green chemistry principles were generally focused on the large scale synthesis and manufacturing phases of drug development as a matter of course to increase efficiency and reduce costs. However, in the last decade, a paradigm shift has occurred with the drive to integrate these principles early on in the discovery phase. As a result, both at Pfizer and many other companies in the pharmaceutical industry, the principles of green chemistry have become much more prominent such that all programs are realizing some form of “green” enhancement at an earlier stage that is translating to an overall reduction in environmental impact and improved efficiency of the drug discovery process. A short summary of some of the tools that are used and how they are specifically implemented will be presented.

Seamless integration of green chemistry at Pfizer from development to discovery

253rd National Meeting (2017)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.