The development of an effective vaccine construct against tumor associated carbohydrate antigens (TACAs) is an attractive approach towards cancer treatment and prevention.  However, a significant challenge is that TACAs are only weakly immunogenic and direct administration of TACAs cannot elicit a powerful antibody response to protect the host from cancer development.  In this talk, we will present our strategies to significantly enhance the immunogenicity of TACAs as potential anti-cancer vaccines and to better understand structural features critical for the generation of anti-TACA antibodies.

Fighting cancer with a sweet bullet: The development of carbohydrate based anticancer vaccines

253rd National Meeting (2017)

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