The transmembrane protein Notch is involved in many cellular processes, such as cell development and gene transcription. Certain cancers and developmental problems are associated with the malfunction of the Notch protein and its signaling pathway. A more complete understanding of the mechanisms of the Notch signaling pathway would increase the body of scientific knowledge as a whole and could also have medically relevant applications. One previously identified Notch inhibitor, FLI-06, is useful in the study of Notch signaling because it is thought to act later in the Notch signaling pathway than other previously identified Notch inhibitors. Derivatization of this compound will allow for structure activity relationship testing that may lend itself to a more complete picture of how Notch signaling takes place. The objective of this project is the continued structural variation of FLI-06 to allow for analysis of the inhibitory capabilities of the resulting derivatives. Specifically, attempts toward the organic synthesis of three substituted cyclohexane-1,3-dione compounds that will allow for the derivatization of FLI-06 in one position are described. During weekends this summer, I traveled around Germany and the Czech Republic eating delicious food, learning about other places, and experiencing daily life in other regions of the world firsthand. Through my immersion into diverse cultures, I was made more aware of how people in different places view and experience the world.

Performing synthesis and gaining cultural awareness in Germany

253rd National Meeting (2017)

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