Current cancer treatments selectively terminate rapidly dividing cells which can cause adverse off target side effects such as hair loss and gastrointestinal problems. This paper focuses on the synthesis of ALK5 kinase inhibitors, and their role as possible chemotherapeutic agents. Due their structural similarities to known inhibitors, the compounds outlined are predicted to bind to ALK5 kinase. However, in contrast to current chemotherapies, these compounds have been designed to switch between active and inactive conformations in response to a given wavelength of light. The potential of these compounds for controlled and specialized treatment of only malignant cells when active, is discussed.

Progress toward the synthesis of a photosensitive ALK5 inhibitor

253rd National Meeting (2017)

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