Hydrogen sulfide (H2S) donors are important research tools that also have potential for pharmacological applications in disease states in which exogenous H2S administration exhibits a positive impact. A significant challenge in sulfide donation is that most available donors release H2S passively, rather than in response to specific stimuli. In response to these challenges, we recently demonstrated that carbonyl sulfide (COS)-releasing molecules can be leveraged to access H2S donors, due to the rapid hydrolysis of COS to H2S by the ubiquitous enzyme carbonic anhydrase. This presentation will focus on recent work from our lab focused on the development and application of responsive COS/H2S donors triggered by specific stimuli, such as biologically-relevant reactive species, click partners in biorthogonal reactions, as well as other efficient triggering reactions.

Responsive chemical tools for COS and H2S delivery

253rd National Meeting (2017)

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