The ability to substitute hemoproteins with non-native cofactors has been an area of research for decades due to their inherent abilities of some hemoproteins to withstand extraction of heme and replacement with heme analogs. We are applying this protein engineering strategy to target small molecules susceptible to oxidation to provide for new entries into biocatalysis. This study will focus on progress that has been made by substituting the oxygen carrying protein, myoglobin, with manganese porphyrin and porphyrin-derivatives. We have discovered that these manganese-substituted proteins promote C-H bond oxidation.<br/>

Preparation of synthetic conjugated myoglobin to promote new reactivity

253rd National Meeting (2017)

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