Natural products, particularly those with novel structures and biological activity, are privileged starting points in the development of new antimicrobial agents. With the recent resurgence in the search for novel lead structures, rapid and efficient complex molecule synthesis enables the preparation and biological evaluation of interesting new molecules and allows access to analogs not available previously. Our research program is focused on utilizing marine natural products as a platform for chemical and biological discovery and are thereby motivated to explore novel natural product scaffolds with activity against antibacterial-resistant microorganisms as leads for infectious disease research. Specifically, the synoxazolidinone family of 4-oxazolidinone natural products will be discussed. These studies have revealed exciting lead structures for both biofilm and antibiotic development and chemical methods applicable to important, yet hard to access, motifs.

Synthesis and biological evaluation of novel heterocyclic scaffolds as infectious disease lead compounds

253rd National Meeting (2017)

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