Microencapsulation technique can efficiently accommodate solid, liquid or gaseous substances within a shell of another substance, creating small sealed capsules. Diffusion of embedded material through the shell walls can be monitored with the structure of the capsule, resulting in controlled release under given conditions of applications. With microencapsulation, a functional barrier is constructed between the packed species and the surrounding wall material, maintaining biological, functional and physicochemical properties of the active material and preventing chemical and physical reactions. Presented study delves into the design and construction of cellulose derivative-based microcapsules, which serve as (i) carriers of active species or (ii) possess functional shell surface. In the first instance, α-tocopherol-loaded ethyl cellulose microcapsules, applied as a functional coating for treatment of skin (α-tocopherol, i.e. vitamin E acts as a scavenger for free radicals, preventing skin damage), will be presented. Surfactant-assisted fabrication of microcapsules was carried out using different process parameters and a variety of surfactants, which results in differences in size, size distribution of particles and surface topography and effectively influences their packing and release properties. The second cellulose microcapsule system tackles the applications pertaining to isolation and separation of specific molecules, essential procedures in a variety of bioscience and biotechnology areas. Here, magnetic particle-based bioseparation is one of the most widely used; we have constructed capsules with magnetic shells, which serve as efficient platform for isolation of e.g. proteins.<br/>

Cellulose-based microcapsules: Bio-compatible vessels for packing, delivery and attachment of active species

253rd National Meeting (2017)

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