The fructans from <i>Agave tequilana Weber var. azul </i>(ATF) have a great potential as carriers of drugs to the colon due to their chemical structure, which contains β 2-1 linkages and make them non digestible in upper digestive tract. Additionally, ATFs have β 2-6 branches, which make them more readily soluble for further chemical modifications. ATFs are enzymatically degradable in the colon. The design of new drugs requires better transport and delivery systems. ATF derivatives (esters such as acetates, succinates or alkylates) have a great potential for designing technologies for controlled release. ATF esters can be tailored to meet different partition coefficients that promote their self-association thus enabling encapsulation capacity. In this work we esterified ATF with acetate, succinate, lauryl and mirystoyl esters, studied their solution and association behavior (critical micelle concentration, rheology and density of the solutions) and their capacity to encapsulate ibuprofen as model drug.

Self assembly of <i>A. Tequilana</i> fructans and encapsulation of ibuprofen for targeting oral drugs to the colon

253rd National Meeting (2017)

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Self assembly of A. Tequilana fructans and encapsulation of ibuprofen for targeting oral drugs to the colon