N-Acetyl Neuraminic Acid is the most abundant member of sialic acids and is predominately found at the terminal ends of glycoconjugates in mammalian cells.  These carbohydrates participate in cell-cell interactions in organisms and play a role in the development of infectious diseases such as influenza.  Sialylations for the synthesis of sialyl-containing glycoconjugates are often performed with poor yields and/or stereoselectivities. As a part of a program focused on the effect of O protecting groups in sialylations, we report herein the synthesis of several C-7 substituted sialyl donors.<br/>

Synthesis of 7-O-substituted derivatives of N-acetyl neuraminic acid

253rd National Meeting (2017)

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