Hunanamycin A (HA), a natural product isolated in small quantities from Bacillus hunanensis, has exhibited antibacterial properties against Salmonella and E. Coli. Synthetic intermediates en route to HA, and related derivatives, may exhibit antibacterial activity. Our current route begins with a methods development study focused on the intramolecular conjugate addition / electrophilic aromatic substitution (CA/EAS) of acrylolyated aniline derivatives. To obtain the starting materials for CA/EAS, amide formation studies have commenced. The requisite amides have been obtained in limited quantities with some impurities; purification of the products, scale-up, and optimization is currently underway.

Amide formation studies en route to Hunanamycin A

253rd National Meeting (2017)

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