We have initiated studies toward an optimized synthesis of 2-bromo-4,5-dimethylaniline; this substituted aniline derivative will likely serve as the requisite starting material in route to Hunanamycin A (HA). Our studies will commence with a two-step synthesis based on the work of Guo et al. We plan to employ relatively inexpensive chemicals and operationally simple procedures; ideally, this will create an accessible, user friendly, and reproducible synthetic protocol. This work will enable longer-term project goals toward the synthesis of HA; an antibacterial natural product found in a marine derived <i>Bacillus hunanensi.</i>

Synthetic studies toward 2-bromo-4,5-dimethylaniline en route to hunanamycin A

253rd National Meeting (2017)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.