The synthesis of heterocycles is of particular interest to medicinal chemists and organic chemists alike. These biologically relevant structures have long inspired the development of new synthetic methodology. One particular heterocycle, oxadiazoles, have shown promise as treatments for cancer, cystic fibrosis, and HIV. A methodology using a phosphorane reagent is presented. This method gives high yields and a broad substrate scope. Extension of this reaction to a two-step, one-pot procedure is also presented, demonstrating a mild, cost-effective means to synthesizing oxadiazoles.

Synthesis of 1,3,4-oxadiazoles using dibromotriphenylphosphorane

253rd National Meeting (2017)

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