The G-protein coupled receptor GLP-1R is a critical protein involved in the regulation of insulin production. As such, stimulating the activity of this protein could lead to new methods of treatment for Type II diabetics. In order to create a molecule that activates this receptor, it is important to understand the molecular structure and folding of the protein. T-0632 is the only small molecule ligand known to bind to GLP-1R in a position proximate to that of the biological ligand. Through the use of photolabile derivatives of T-0632, the binding interactions of the molecule with this protein can be determined. These binding interactions are then used to model the three-dimensional structure of GLP-1R. Whereas previous research has employed photoreactive aryl azides within the ring complexes of T-0632, this research focuses on the synthesis of a photolabile T-0632 derivative via generation of a photoreactive diazocarboxylic acid.<br/>

Synthesis of a photolabile derivative of T-0632 to study GLP-1R

253rd National Meeting (2017)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.